MADISON, Wis. -- Trevon Hughes scored 19 of his career-high 26 points in the second half and Wisconsin held on to beat No. 6 Duke, 73-69, snapping the Blue Devils' perfect record in the Big Ten/ACC Challenge.
The Badgers (5-1) never trailed and got a measure of payback against Duke (6-1) after being routed 82-58 two years ago in Durham, N.C., by ending the Blue Devils' 10-game winning streak in the annual event and the ACC's perfect record as well.
When Ohio State beat Florida State 77-64 in the final game, the Big Ten won the series for the first time, 6-5.
Kyle Singler scored 17 of his career-high 28 points in the first half and Andre Dawkins went 4 of 4 from 3-point range in the second half to finish with 12 for Duke.
Illinois 76, No. 18 Clemson 74:
Mike Tisdale hit the go-ahead jumper with 41 seconds left, then blocked David Potter's driving shot on Clemson's next possession as Illinois rallied from 23 points down for a victory.
Down 51-28 early in the second half, Illinois (5-2) finally got going with a 35-10 run to move in front in the school's biggest comeback ever.
Mike Davis had 22 points for Illinois, whose biggest previous rally came in 2000 when it came from 21 points down to defeat Seton Hall, 87-79.
Demontez Still, who led the Tigers with 15 points, missed a driving shot at the buzzer for Clemson (6-2). Leading scorer Trevor Booker had just three of his 12 points in the second half.
Former Deerfield-Windsor star Andre Young scored 9 points in the loss.
No. 15 Ohio St. 77, No. 21 Florida St. 64
Evan Turner had 25 points and 13 rebounds and Jon Diebler added 22 points to lead Ohio State past Florida State, clinching the Big Ten's first victory in 11 years of its annual series with the ACC.
The conferences came into the night with three wins apiece in head-to-head matchups. Wisconsin's upset of Duke set the stage for the Buckeyes (6-1) to put the Big Ten over the top, ending a decade of frustration against the Atlantic Coast Conference.
Reserve Jeremie Simmons added 14 points for the Buckeyes, who improved to 3-5 in the annual series with the ACC, with another win vacated by NCAA violations in 2000.
Solomon Alabi had 21 points for the Seminoles (6-2), perhaps road weary after playing their last six games away from home. Chris Singleton, the MVP of last weekend's Old Spice Classic, fouled out with eight points and eight rebounds.
No. 1 Kansas 98, Alcorn State 31:
Cole Aldrich had 13 points and 16 rebounds, and top-ranked Kansas scored 36 straight points in the first half in an embarrassingly easy 98-31 victory over winless Alcorn State on Wednesday night.
Kansas (6-0) made quick work of the Braves, forcing a school record-tying 30 turnovers and dunking its way within one of the NCAA record for consecutive points with its big run.
Sherron Collins and Xavier Henry had 18 points each, and Thomas Robinson had 15 points and 10 rebounds to help Jayhawks stretch the nation's longest home winning streak to 46 games.
Alcorn State (0-10) shot 23 percent for its second loss of at least 60 points this season. JaMarkus Holt led Alcorn State with 10 points.
No. 3 Villanova 77, Drexel 58:
Antonio Pena scored a career-high 19 points and grabbed 11 rebounds, and Taylor King added 16 points as Villanova overcame a sluggish start to handily defeat Drexel.
Scottie Reynolds had 14 points, eight rebounds and six assists for the Wildcats (7-0), who improved to 18-1 all-time against the Dragons.
Villanova has won 32 consecutive games at The Pavilion, its 6,500-seat arena. The streak began with a 102-87 win over Notre Dame on Jan. 17, 2007.
Derrick Thomas scored a career-high 23 points while Chris Fouch added a career-high 20 for Drexel (3-5), which shot 31 percent (18 of 58).
No. 11 Tennessee 78, ETSU 66:
Tyler Smith scored 15 points and Tennessee held off scrappy East Tennessee State.
A steal and a fastbreak layup by ETSU's Justin Tubbs with 15:52 left cut the Vols' lead to 42-39. Tennessee (6-1) answered with an 11-2 run capped by a layup by Wayne Chism that boosted the lead to 53-41.
Tubbs led the Buccaneers (4-4) with 22 points.
No. 14 Connecticut 92, Boston U. 64:
Jerome Dyson scored 22 points and Connecticut bounced back from its first loss of the season with a rout of Boston University.
Kemba Walker had 15 points and 10 assists for the Huskies (5-1), while Stanley Robinson added 16 points and nine rebounds. Gavin Edwards chipped in with 12 points and nine boards.
John Holland led the Terriers (2-6) with 23 points and Jake O'Brien added 18 points and 10 rebounds.
UConn, which was outrebounded by 13 in its loss to No. 6 Duke last Friday, had no problems with the smaller Terriers, outrebounding them 54-29.
No. 17 Gonzaga 74, Washington St. 69:
Matt Bouldin scored a career-high 28 points and Gonzaga rallied to beat Washington State.
Elias Harris added 24 points and 12 rebounds for Gonzaga (6-1), which held the Cougars without a field goal for 10 minutes in the late going. The Bulldogs came back from a 13-point second-half deficit to win behind seven 3-pointers by Bouldin.
Klay Thompson scored 15 points to lead Washington State (6-1), but that was 13 points below the season average for the nation's leading scorer.
No. 19 Texas A&M 84, Prairie View A&M 59:
Khris Middleton scored 17 points and Texas A&M shook off a shaky start to beat Prairie View A&M.
Middleton hit consecutive 3-pointers during a key surge late in the first half that put the Aggies (6-1) in control.
Michael Griffin had 16 points for Prairie View (3-3), which scored the first six points of the game and opened a 15-6 advantage nearly four minutes in.
The Aggies grabbed their first lead at 23-21 with 4:29 remaining in the first half and never looked back. They built a 35-25 lead at the break, outscoring Prairie View 18-4 over the final 7:09.
No. 20 Louisville 80, Stetson 48:
Jerry Smith broke out of a shooting slump to score 17 points and lead Louisville.
Samardo Samuels added 15 points and seven rebounds while Edgar Sosa had 15 points and five assists for the Cardinals (5-1), who had little trouble bouncing back from a loss to UNLV last Saturday.
A.J. Smith led the Hatters (2-5) with 18 points, but Stetson shot 35 percent from the field and was simply no match for Louisville once the Cardinals got going midway through the first half.
Louisville used an 11-0 run to take control after a sluggish start.
No. 23 Butler 59, Ball St. 38
No. 23 Butler opened with a flurry of 3-pointers, locked down on defense and rolled to its 14th consecutive win against a fellow school from Indiana.
The Bulldogs (5-2) needed a confidence boost after losing two of three games, both to Top 25 opponents, on their recent trip to California, and the Cardinals (2-3) were the perfect remedy.
Gordon Hayward, last season's Horizon League newcomer of the year, scored 15 points and had eight rebounds for Butler
Ball State shot 19 percent from the field in the first half and 31.7 percent for the game, produced only 11 first-half points and committed 18 turnovers. Malik Perry had 11 points and Jarrod Jones added nine for the Cardinals, who have lost three straight.
No. 24 UNLV 74, Arizona 72, 2 OT
Derrick Jasper hit a 3-pointer with 1:39 left in the second overtime to help UNLV beat Arizona.
Jasper's 3 tied the game at 70. After Arizona sophomore Kyle Fogg missed a contested driving layup with 28 seconds left, TreVon Willis made two free throws to give the Runnin' Rebels (6-0) the lead for good.
Matt Shaw made one free throw to make it 73-70 and Arizona's Nic Wise raced down court but was fouled so he couldn't get off a 3-point attempt to tie. Wise hit both free throws to make it 73-72 with 9 seconds left.
Kendall Wallace hit the second of two free throws to make it 74-72, and Wise's last shot was blocked by Justin Hawkins as time expired.
Willis had 25 points for UNLV, while Derrick Williams led the Wildcats (3-3) with 28 points.
Portland St. 86, No. 25 Portland 82
Dominic Waters scored 21 of his 23 points in the second half and Portland State rallied past Portland in the Pilots' first game as a ranked team in 50 years.
The Vikings (2-4) have won four consecutive games over cross-town rival Portland (5-2), which was ranked for three weeks in the 1958-59 season.
Portland led 74-62 with 9:20 left, but Portland State reeled off 10 straight points, including consecutive 3-pointers by Waters and Paul Guede, to quickly trim the deficit.
Portland State took the lead at 81-80 when Waters hit a 3-pointer with 3 minutes remaining.
The Vikings pushed the lead to 85-82 on two free throw by Waters with 22 seconds left. Portland had a chance to tie but Nik Raivio's 3-point attempt from the corner was off the mark.