HOUSTON -- Peyton Manning threw for three touchdowns and the Colts rallied from a 13-point halftime deficit Sunday for a 35-27 win to clinch the AFC South.
It was their 20th straight regular-season victory. Indianapolis (11-0) is one win shy of the New England Patriots' NFL-record 21-game run from 2006-08. The Colts can tie the record if they beat Tennessee at home next weekend.
The Colts improved to 15-1 against Houston (5-6).
Manning threw two first-half interceptions, but had a pair of second-half TD passes, including a 4-yarder to Dallas Clark that gave the Colts a 21-20 lead with about nine minutes left.
Clint Session stretched the lead to 28-20 when he returned an interception by Matt Schaub 26 yards for a touchdown seconds later. Schaub fumbled on Houston's next possession and Chad Simpson's touchdown run put the game out of reach.
The loss makes Houston's chances of earning its first playoff berth more dim after losing three straight. The Texans scored on their first four possessions, then fell apart.
Titans 20, Cardinals 17: Vince Young hit a leaping Kenny Britt for a 10-yard touchdown as time expired, and the Titans rallied for their fifth straight victory.
Young won his ninth straight start and improved to 23-11 in his career by driving the Titans 99 yards in the final 2:37. He converted three fourth downs on the drive, two to Britt. He threw for a career-high 387 yards in outdueling Matt Leinart in their first meeting as professionals.
The Titans (5-6) have not lost since Young replaced Kerry Collins as the starter. They are the first team to win five in a row after starting 0-6.
Arizona (7-4) snapped a three-game winning streak. Leinart made his first start since Oct. 7, 2007 as the Cardinals sat Kurt Warner with a sore neck, looking ahead to an NFC matchup with Minnesota next week.
Chargers 43, Chiefs 14: The Chargers turned four turnovers into touchdowns, including a 40-yard fumble return for a score by safety Paul Oliver, and ran their winning streak to six games.
LaDainian Tomlinson scored two touchdowns and moved into 10th on the NFL's career rushing list. Philip Rivers threw two touchdown passes to Antonio Gates as the Chargers improved to 8-3.
The Chiefs (3-8) lost a week after stunning the defending Super Bowl champion Pittsburgh Steelers in overtime.
Tomlinson began the day 12th on the all-time list with 12,218 yards. He passed Marcus Allen (12,243) on a 5-yard carry in the first quarter and Edgerrin James (12,246) on an 8-yard run in the second.
Tomlinson had 39 yards on 13 carries, giving him 12,257 for his career. Up next is Marshall Faulk in ninth with 12,279 yards.
Rivers was 21 of 28 for 317 yards, with no interceptions, for a rating of 135.6. He wasn't sacked.
A defense that lost outside linebacker Shawne Merriman to a foot injury in the second quarter still came up big. Cornerback Quentin Jammer had an interception and forced a fumble, and Brandon Siler and rookie Larry English also recovered fumbles.
Vikings 36, Bears 10: Brett Favre passed for a season-high 392 yards and three touchdowns, and the Vikings intercepted Jay Cutler twice.
Favre went 32 for 48 without a turnover and was 10 yards off his career best, throwing touchdowns to Visanthe Shiancoe, Chester Taylor and Percy Harvin, the unflappable rookie who had his best game yet.
The Vikings (10-1) outgained the Bears by a whopping 537 yards to 169 and breezed to their fifth straight win despite two more fumbles and a pedestrian 85 yards on 25 carries by Adrian Peterson.
His short, late touchdown run put Minnesota over 32 points for the sixth time this season. The Vikings had 31 first downs, the Bears (4-7) just eight.
Bengals 16, Browns 7: Newcomer Larry Johnson rushed for 107 yards in Cincinnati's conservative approach, and the Bengals completed their first division sweep.
The Bengals (8-3) went 6-0 in the division with a retooled run-first offense and a stout defense that has carried them into first place. They rushed for 210 yards, with Johnson -- signed less than two weeks ago as insurance -- subbing for Cedric Benson, out for the second straight week with an injured hip.
The Browns (1-10) reached double-digit losses for the eighth time in their 11 years as an expansion team. Cincinnati now has the longest stretch of domination in the series' history, winning nine of the past 11 games.
Eagles 27, Redskins 24: David Akers kicked a 32-yard field goal with 1:48 remaining and the Eagles rallied. A week ago, Donovan McNabb led the Eagles (7-4) to a late touchdown in a 24-20 win at Chicago. It was the first time Philadelphia came from behind in the final quarter and won since a 33-25 victory at Washington on Nov. 11, 2007.
Akers made all four of his field goals, extending his streak to 16. Asante Samuel had two interceptions and McNabb threw for 260 yards and one TD.
Bills 31, Dolphins 14: A 56-yard field goal by Rian Lindell and a 51-yard touchdown catch by Terrell Owens in the final minutes propelled the Bills, who scored 24 points in the fourth quarter. The win was the first for interim coach Perry Fewell, who replaced the fired Dick Jauron two games ago.
Jets 17, Panthers 6: Darrelle Revis got the Jets' defense in the end zone for the first time this season. Revis returned one of the Jets' four interceptions 67 yards for a touchdown and New York overcame an injury scare to quarterback Mark Sanchez.
Thomas Jones had a 3-yard touchdown run as the Jets (5-6) won at home for the first time since beating Tennessee in Week 3, sending the Panthers (4-7) to their second straight loss.
Seahawks 27, Rams 17: Justin Forsett set career highs with 130 yards and two touchdowns and the go-ahead score came on the Seahawks' third defensive touchdown of the season.
Seattle (4-7) had been 0-5 on the road but ended the drought against the Rams (1-10), who have lost 11 in a row at home.