KEY WEST, Fla. (AP) - The National Hurricane Center predicted Isaac would grow to a hurricane over the warm Gulf of Mexico and possibly hit late Tuesday somewhere along a stretch that starts west of New Orleans and runs to the edge of the Florida Panhandle. That would be one day shy of seven years after Hurricane Katrina struck catastrophically in 2005.
In the Florida Keys, Monroe County Sheriff's spokeswoman Becky Herrin said there were no injuries and few reports of damage as the storm crossed near Key West on Sunday.
Much of the rest of South Florida remained under a tornado watch early Monday as the remnants of Isaac moved across the area.
In Tampa, flooding prompted the brief closure of several main roads early Monday including three near downtown where the Republican convention was to be held.
Elsewhere, people were preparing for a possible hit from a hurricane.
"I'm helping my friend pack and board up his beach house just in case (Isaac) makes its way over here," Pensacola resident Andrew Flock said Sunday.
Louisiana Gov. Bobby Jindal called a state of emergency, and 53,000 residents of St. Charles Parish near New Orleans were told to leave ahead of the storm.
Mississippi Gov. Phil Bryant and Alabama Gov. Robert Bentley also declared states of emergency.
Meanwhile, the oncoming storm stopped work on rigs that account for 24 percent of daily oil production in the U.S. potion of the Gulf of Mexico and eight percent of daily natural gas production there, the federal Bureau of Safety and Environmental Enforcement said in its latest update Sunday.
Several area governors have altered their plans for this week's GOP convention in Tampa. Bentley has canceled his trip, and Jindal said he's likely to do so unless the threat from the storm subsides. Florida Gov. Rick Scott gave up a chance to speak.
A hurricane warning was in effect for an area that covers a roughly 300-mile stretch of the Gulf Coast in four states from Louisiana to the Florida Panhandle. Tropical storm warnings were effect for a section of Louisiana's Gulf Coast from Morgan City to Intracoastal City. Tropical storm warnings were also in effect for many areas along Florida's Gulf Coast.
Amtrak cancelled train service in Louisiana for Tuesday and Wednesday. The route than runs from New York to New Orleans would end in Atlanta, while its route from Los Angeles to New Orleans would stop in San Antonio. Amtrak was also suspending part of its rail line between Miami and Orlando, Fla.
Grocery and home improvement stores as well as fuel stations in Louisiana reported brisk business as residents sought to prepare for Isaac. Some gas stations were running out of supplies.
Even though the storm was moving well west of Tampa, tropical storm-force winds and heavy rains were possible in the area because of Isaac's large size, forecasters said. A small group of protesters braved rainy weather Sunday and vowed to continue despite the weather, which already forced the Republicans to cancel Monday's opening session of the convention. Instead, the GOP will briefly gavel the gathering to order Monday afternoon and then recess until Tuesday.
Tampa Mayor Bill Buckhorn, a Democrat, said the weather would be "squirrely" but predicted the storm would not unduly interfere with the convention.
"We're going to show the world on Tuesday, Wednesday and Thursday what a great place this is," he said. "As a state and a city, we're going to put on a good show and be a great host for the Republican Party."
As of 5 a.m. EDT Monday, the storm was centered about 180 miles (290 kilometers) southwest of Fort Meyers, Fla., and 405 miles (650 kilometers) southeast of the mouth of the Mississippi River, according to the National Hurricane Center in Miami. Isaac had top sustained winds of 65 mph (100 kph) and was moving west-northwest near 14 mph (22 kph).
Florida, historically the state most prone to hurricanes, has been hurricane-free since it was hit four times each in 2004 and 2005. Isaac will likely prove barely a memory for South Florida and Keys residents, who mostly took the storm in stride as its center passed just south of Key West on Sunday.
"This is routine for us," said Annie Lopez, 47, a lifelong Key West resident. "It's down to a science."
The storm did knock out power temporarily for around 16,000 customers throughout South Florida, and 555 flights were canceled at Miami International Airport. That forced some people to shuffle their travel plans and kept many, at least for a day, from enjoying their beach vacations.
"I have friends who tell me to come in January," said Peter Muller, who was visiting Miami with his family from Germany. They spent part of Sunday at a Miami-area mall. "Maybe they know best."
In the low-lying Keys, isolated patches of flooding were reported and some roads were littered with downed palm fronds and small branches. But officials said damage appeared to be minimal, and many Keys residents held true to their any-excuse-for-a-party reputation.
"The storm was the most fun thing ever!" exclaimed Sergey Jadzevics, who were taking pictures on famed Duval Street in Key West, a fresh bottle of vodka in hand.
The Gulf Coast hasn't been hit by a hurricane since 2008, when Dolly, Ike and Gustav all struck the region.
Before reaching Florida, Isaac was blamed for eight deaths in Haiti and two more in the Dominican Republic, and downed trees and power lines in Cuba. It bore down on the Keys two days after the 20th anniversary of Hurricane Andrew, which caused more than $25 billion in damage and killed 26 people in South Florida.